SENTIS™ Hereditary Cancer Panel

Introduction

SENTIS™ Hereditary Cancer Panel screens for inherited cancer-causing mutations that are associated with an increased risk of developing specific cancer types in an individual.

SENTIS™ Hereditary Cancer Panel offers comprehensive screening on up to 90 genes associated with 24 important cancers. Identification of inherited cancer-causing mutations helps to confirm a diagnosis, guide treatment and health management decisions, and give guidance family members who could be under the same cancer risk.

Comprehensive

Whole exome plus flanking intronic regions covered for all genes tested; one single assay that detects point mutations, deletions, insertions, duplications and rearrangements

Robust

Clinically important (pathogenic or likely pathogenic) variants are verified by Sanger Sequencing, while large gene rearrangements are verified by qPCR

Convenient

Test from blood or saliva; DNA is also accepted

Professional

A state-of-the-art variant database ensures up-to-date analysis and interpretation. We also have a dedicated genetic counselling team offering professional genetic counselling services via email

Sample Requirement

2ml Saliva; or
5-8ml Peripheral Blood in EDTA tube

Screening Package Options

Comprehensive Panel

Hereditary Cancer Panel (Female Package): 85 genes for 24 cancers

Hereditary Cancer Panel (Male Package): 90 genes for 23 cancers

Targeted Panel

BRCA1 and BRCA2

Hereditary Breast and Ovarian Cancer (HBOC)

Hereditary Colorectal Cancer

Hereditary Pancreatic Cancer

Hereditary Prostate Cancer

Hereditary Retinoblastoma

Hereditary Gastric Cancer

Hereditary Renal Carcinoma

Hereditary Multiple Endocrine Neoplasia

Hereditary Thyroid Cancer

Hereditary Parathyroid Carcinoma

Hereditary Neurofibromatosis

Hereditary Pheochromocytoma

Familial Paraganglioma

Hereditary Melanoma

Hereditary Chondrosarcoma

Hereditary Endometrial Cancer

Hereditary Gastrointestinal Stromal Tumor

Hereditary Esophageal Cancer

SENTIS™ Hereditary Cancer Panel

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